Glucokinase Isoform 2

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 TYR-61   VAL-62  11.0 12.6 25.1 -16.8 150.7 139.5 -7.3
 VAL-62   ARG-63  9.3 10.4 -72.6 36.2 55.4 41.4 20.3
 ARG-63   SER-64  11.9 13.6 20.3 -106.8 171.9 149.4 85.6
 SER-64   THR-65  12.8 14.4 -26.5 -110.0 65.2 78.8 -163.2
 THR-65   PRO-66  10.2 17.8 84.2 28.4 92.2 124.5 76.2
 PRO-66   GLU-67  11.7 19.9 -82.2 -46.2 66.6 114.1 -24.1
 GLU-67   GLY-68  10.5 19.6 -166.5 3.0 116.6 68.3 -36.6
 GLY-68   SER-69  10.5 16.4 -100.7 51.2 119.9 109.5 -18.9
 SER-69   GLU-70  7.7 13.8 -3.6 -32.6 92.3 52.3 29.6
 GLU-70   VAL-71  9.2 11.0 33.0 22.7 104.6 59.1 2.3
 VAL-71   GLY-72  8.9 9.0 135.9 174.8 51.5 83.8 -13.8
 GLY-72   ASP-73  10.5 5.5 147.5 51.0 68.0 48.0 174.7
 ASP-73   PHE-74  10.7 7.0 17.2 -60.1 26.2 35.0 -34.5

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 GLY-92   GLU-93  7.0 10.1 -14.7 18.1 115.0 151.8 1.8
 GLU-93   GLY-94  6.0 11.0 -160.7 -155.6 154.4 135.5 38.2
 GLY-94   GLU-95  3.4 11.0 -31.7 27.5 119.4 138.2 0.4
 GLU-95   GLU-96  3.0 13.2 52.4 -72.7 117.1 45.2 3.4
 GLU-96   GLY-97  3.2 11.6 24.1 -80.6 149.9 116.1 52.6
 GLY-97   GLN-98  3.3 11.9 157.9 22.6 107.5 97.1 27.7
 GLN-98   TRP-99  2.1 8.2 106.3 -70.0 83.6 158.8 -19.1
 TRP-99   SER-100  3.4 6.8 -40.4 18.0 28.9 71.6 15.4
 SER-100   VAL-101  5.7 6.2 10.2 19.3 83.8 171.6 -23.1
 VAL-101   LYS-102  9.4 5.5 -51.5 6.9 35.3 73.3 32.5
 LYS-102   THR-103  11.9 8.5 24.1 -24.1 72.5 155.0 -5.1
 THR-103   LYS-104  14.6 8.7 -176.5 -1.1 49.5 69.5 -152.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 MET-197   ASP-198  10.6 15.8 -151.7 52.5 82.1 131.2 -89.5
 ASP-198   VAL-199  8.7 13.5 -151.5 -63.2 106.2 111.2 -90.9
 VAL-199   VAL-200  4.9 9.9 83.9 -72.3 65.3 111.3 -14.5
 VAL-200   ALA-201  4.8 8.9 153.1 105.7 84.4 83.7 53.6
 ALA-201   MET-202  2.0 6.0 -1.3 -27.5 69.2 134.7 60.0
 MET-202   VAL-203  2.6 5.5 -18.6 2.5 116.3 84.2 -17.9
 VAL-203   ASN-204  5.8 5.5 -179.8 29.6 78.1 110.4 -3.6
 ASN-204   ASP-205  9.4 9.0 -27.6 -0.4 144.7 145.3 -15.9

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees