DynDom - Protein Domain Motions

Integrin Beta-3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Integrin Beta-3
Conformer 1 (PDB)	3fcs (B)
Conformer 2 (PDB)	3fcu (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	237	1.99	108 - 344
2	214	1.81	3 - 107 345 - 459

Sequence

`___________________________________________________________________________________________________106__________________` `3fcs(B) : GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSqVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSM` `:` `3fcu(B) : GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDK--qVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSM` `___________________________________________________________________________________________________106__________________` `________________________________________________________________________________________________________________________` `3fcs(B) : KDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASH` `:` `3fcu(B) : KDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASH` `________________________________________________________________________________________________________________________` `______________________________________________________________________________________333_______________________________` `3fcs(B) : LLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPE` `:` `3fcu(B) : LLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPE` `______________________________________________________________________________________333_______________________________` `________________________________________________________________________________________________________________________` `3fcs(B) : ELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEqDECSPRE` `:` `3fcu(B) : ELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCR*********************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3fcs(B) : GQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTF` `:` `3fcu(B) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________` `3fcs(B) : KKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECCKG` `:` `3fcu(B) : ******************************************************************************` `________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	61.9
Translation (A)	0.7
Closure (%)	45.1
Bending Residues ( green )	106 - 111 333 - 355
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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