DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor 5

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor 5
Conformer 1 (PDB)	6n4x (A)
Conformer 2 (PDB)	3lmk (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	267	0.66	27 - 194 331 - 461 463 - 463
2	167	0.94	195 - 330 462 - 462 464 - 493

Sequence

`________________________________________________________________________________________________________________________` `6n4x(A) : ERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISkKPIVGVIGPGSSSVAIQVQNLLQ` `:` `3lmk(A) : RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRD-----kPIVGVIGPGSSSVAIQVQNLLQ` `________________________________________________________________________________________________________________________` `____________________________194_________________________________________________________________________________________` `6n4x(A) : LFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTV` `:` `3lmk(A) : LFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGISIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTV` `____________________________194_________________________________________________________________________________________` `____________________________________________330_________________________________________________________________________` `6n4x(A) : RGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINA` `:` `3lmk(A) : RGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEG--------nKTCNSSLTLKTHHVQDSKMGFVINA` `____________________________________________330_________________________________________________________________________` `_______________________________________________________461______________________________________________________________` `6n4x(A) : IYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVI` `:` `3lmk(A) : IYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD*************************` `_______________________________________________________461______________________________________________________________` `__________________________` `6n4x(A) : RKGEVSCCWTCTPCKENEYVFDEYTC` `:` `3lmk(A) : ************************` `__________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	29.0
Translation (A)	0.4
Closure (%)	99.4
Bending Residues ( green )	194 - 196 330 - 332 461 - 466
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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