Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB) 		3hqp (K)
  Conformer 2
(PDB) 		2vgb (D)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 387 2.09   7 - 88   179 - 183   189 - 492
2 92 1.66   89 - 178   184 - 188

Sequence


           ________________________________________________________________________________________________________88______________ 
 3hqp(K) : ***********SQLAHNLTLSI-FDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGQFVGGDAVME 
         :                                                                                                                          
 2vgb(D) : QQQQLPAAMADTFLEHLCLLDIDSEPVAA-RSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTG--IeSEVELV 
           _______________________________________________________________________________________________________161______________ 

           _________________________________________________________________________178__183__188__________________________________ 
 3hqp(K) : RGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQVGDV 
         :                                                                                                                          
 2vgb(D) : KGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEG-LVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAV 
           _________________________________________________________________________253__258__263__________________________________ 

           ________________________________________________________________________________________________________________________ 
 3hqp(K) : RKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEV 
         :                                                                                                                          
 2vgb(D) : RAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEA 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3hqp(K) : VQYMARICLEAQSALNEYVFFNSIKKLQHIPMSAD--EAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF--DADKLGHDEGKEHRVA 
         :                                                                                                                          
 2vgb(D) : VKMQHAIAREAEAAVYHRQLFEELRRA--APLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADD-VDRRVQ 
           ________________________________________________________________________________________________________________________ 

           ________________________________________                                                                                 
 3hqp(K) : AGVEFAKSKGYVQTGDYCVVIHADHKVKGYANQTRILLVE                                                                                 
         :                                                                                                                          
 2vgb(D) : FGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSI*                                                                                 
           ________________________________________                                                                                 

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		16.9
Translation
(A) 		-0.1
Closure
(%) 		88.1
Bending Residues
( green ) 		  88 - 89
  178 - 179
  183 - 184
  188 - 189
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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