DynDom - Protein Domain Motions

Receptor-Type Tyrosine-Protein Phosphatase Epsilon

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Receptor-Type Tyrosine-Protein Phosphatase Epsilon
Conformer 1 (PDB)	2jjd (B)
Conformer 2 (PDB)	2jjd (C)
Window Length	7
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	293	0.18	114 - 427 429 - 429 653 - 653 657 - 662
2	242	0.28	428 - 428 430 - 652 654 - 656 663 - 688

Sequence

`________________________________________________________________________________________________________________________` `2jjd(B) : KYFPIPVEHLEEEIRIRSkQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLgIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTN` `:` `2jjd(C) : KYFPIPVEHLEEEIRIRSkQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLgIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2jjd(B) : LKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPkAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKV` `:` `2jjd(C) : LKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPkAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKV` `________________________________________________________________________________________________________________________` `_____________________________________________427________________________________________________________________________` `2jjd(B) : DVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSgLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMyTDYINASFIDGYRQKDYFIATQGPLA` `:` `2jjd(C) : DVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSgLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMyTDYINASFIDGYRQKDYFIATQGPLA` `_____________________________________________427________________________________________________________________________` `________________________________________________________________________________________________________________________` `2jjd(B) : HTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNgEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHC` `:` `2jjd(C) : HTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNgEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHC` `________________________________________________________________________________________________________________________` `___________________652_656__661______________________________` `2jjd(B) : SAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID` `:` `2jjd(C) : SAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID` `___________________652_656__661______________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	2.2
Translation (A)	0.1
Closure (%)	7.9
Bending Residues ( green )	427 - 430 652 - 654 656 - 657 661 - 663
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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