DynDom - Protein Domain Motions

Unconventional Myosin

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Unconventional Myosin
Conformer 1 (PDB)	2bkh (A)
Conformer 2 (PDB)	2v26 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	48	3.1	489 - 502 703 - 709 745 - 771
2	638	3.19	7 - 488 504 - 702
3	48	3.19	710 - 744 774 - 786

Sequence

`________________________________________________________________________________________________________________________` `2bkh(A) : GKPVWAPHPTDGFQVGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSETIKSYQGKSLGTM` `:` `2v26(A) : KPVWAPHPTDGFQVGNIVDIGPDSLTIEP----gKTFLALINQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSETIKSYQGKSLGTM` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2bkh(A) : PPHVFAIADKAFRDMKVLKLSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEER` `:` `2v26(A) : PPHVFAIADKAFRDMKVLKLSQSIIVSGESGAGKTENTKFVLRYLTESYG------dRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKEER` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2bkh(A) : NYHIFYRLCAGASEDIRERLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSLKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAg-----CN` `:` `2v26(A) : NYHIFYRLCAGASEDIRERLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYLKAGSLKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGGCN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2bkh(A) : LKNKSTQALEYCAELLGLDQDDLRVSLTTRVMLTTAGGAKGTVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQF` `:` `2v26(A) : LKNKSTQALEYCAELLGLDQDDLRVSLTTRVM-----------iKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQQF` `________________________________________________________________________________________________________________________` `_487____________502_____________________________________________________________________________________________________` `2bkh(A) : FNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEARLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLSIPRKSKLAIHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHM` `:` `2v26(A) : FNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEARLVGILDILDEENRLPQPSDQHFTSAVHQKHKDHFRLSIPRKSKLAIHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHM` `_487____________502_____________________________________________________________________________________________________` `______________________________________________________________________692______________709______________________________` `2bkh(A) : SLESLICESRDKFIRELF-EfISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRASFHELYNMYKKYMPDKLARLDPRLFCKALF` `:` `2v26(A) : SLESLICESRDKFIRELFlSFISVGNKFKTQLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRASFHELYNMYKKYMPDKLARLDPRLFCKALF` `______________________________________________________________________692______________709______________________________` `_743_______________________769___________________________________________` `2bkh(A) : KALGLNEIDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNHWLICSRWKKVQWCSLSVIKLKNKIKY` `:` `2v26(A) : KALGLNEIDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELVKRVNHWL***********************` `_743_______________________769___________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	90.6
Translation (A)	-0.1
Closure (%)	11.6
Bending Residues ( green )	487 - 489 502 - 507 692 - 704
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	53.2
Translation (A)	-0.4
Closure (%)	2.7
Bending Residues ( green )	709 - 710 743 - 745 769 - 774
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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